The Nucleotide Sequence of the lac Operator
نویسندگان
چکیده
منابع مشابه
Lac operator analogues: bromodeoxyuridine substitution in the lac operator affects the rate of dissociation of the lac repressor.
As measured by a decreased rate of dissociation, lac repressor binds 10-times tighter to 5-bromodeoxyuridine-substituted lac operator than it does to normal lac operator. This result is obtained both in the absence and in the presence of isopropylthiogalactoside, an inducing ligand. These data are significant with regard to the mechanism of sequence-specific protein-DNA interaction, and also su...
متن کاملThe lac operator is DNA.
How repressors act at the molecular level to tmrn off genes is only now beginning to be worked out. Most vital to this understanding is whether the operator, defined genetically as the site for the action of a repressor, would turn out to be part of a DNA molecule, a region of a messenger RNA molecule, or even a protein. Now that two specific repressors (lactose and X) are available," 2 it is p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1973
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.70.12.3581